Aplex Bio is at the forefront of advanced molecular testing, delivering platform technologies that expand capabilities in precision genomics, molecular diagnostics, and high-frequency biological screening. Hyperplex PCR, the company’s next-generation platform, introduces a new paradigm in molecular measurement by combining multiplexed detection, molecular counting, and single-nucleotide discrimination in a single workflow. The platform delivers digital-like single-copy sensitivity while scaling to 100+ targets per well, addressing limitations in plex, precision, and cost-efficiency that constrain both traditional PCR and sequencing technologies. Aplex Bio is dedicated to advancing the next generation of molecular diagnostics and enabling technologies for population-scale applications that can contribute to improved healthcare outcomes worldwide. The company is headquartered in Stockholm, Sweden.
We are seeking a scientist to (1) support the development and optimization of customized Hyperplex PCR panels spanning a variety of high impact biological applications and (2) support ongoing R&D developments of new product lines. The successful candidate will report directly to the Chief Scientific Officer and be involved in the improvement and optimization and validation workflows; hands-on experimentation; systematic critical data analysis and documentation, as well as operational logistics of procuring reagents and assembly of the final kit product. The position is ideal for an action-driven problem solver who thrives in an interdisciplinary, fast-paced start-up environment. We are seeking someone with exceptional attention to detail, meticulous organizational skills, and a strong commitment to precise documentation. Your ability to follow data documentation guidelines to the letter, and maintain an organized, detail-oriented approach in all tasks, will be critical in ensuring success. If you pride yourself on your attention to the smallest details and have a passion for keeping things structured and well-documented, this is the perfect role for you.
Responsibilities
- Collaborate closely with the biology team on the performance quality control of primers and probes for specific DNA and RNA targets of interest
- Drive and continuously improve routines of oligo procurement, storage and handling to support multiple parallel custom panel development projects
- Develop efficient optimization and validation workflows according to internal standards and external customer requests
- Support the implementation and expansion of liquid handling automation tools for streamlining production and routine assay execution
- Hands-on preparation of oligo mixes and experimentation aimed at the optimization and validation of new hpPCR panels, as well as ongoing product development projects
- Plan adaptation and scaling of operations to cope with expanding volumes of customization requests
- Compile and analyse large data sets and prepare clear reporting documents for internal and external communication purposes
- Continuously support an efficient communication with the chemistry and software teams for quality assurance and improvement of internal processes
- Routine interactions with new and existing customer-base to provide scientific support, bespoke development of panels according to needs of customers and troubleshooting according to customer feedback
- Keeping up to date with relevant scientific and technical developments
We’re looking for a candidate with a strategic mindset, action-driven approach, and the ability to thrive in a fast-paced and agile environment. This individual should possess meticulous attention to detail and a proactive approach to achieving project milestones, as well as the flexibility to adapt to evolving methods. The ideal candidate can communicate effectively at all organizational levels, build strong relationships with team members and existing customers, and demonstrate a genuine passion for making a disruptive impact in molecular diagnostics.
Required:
- MSc or PhD degree in Biotechnology, Bioengineering, Biomedicine, Microbiology or related fields
- Experience running and optimizing qPCR and/or digital PCR assays
- Basic knowledge of statistical analysis, including data classification, regression, clustering and visualization
- Strong laboratory skills and hands-on approach
- Excellent ability to characterize and navigate complex problems to find solutions
- Strong written and verbal communication skills in English.
- Valid work authorization for Sweden
Preferred:
- At least 2 years of industry experience
- Experience with bioinformatic tools for primer design, sequence alignment and basic programming tools
- Experience in Library preparation for Next-generation sequencing
- Experience in Fluorescence Microscopy
- Experience in lab management and Laboratory Information Management Systems (LIMS)
- Experience with multiplexed detection of biomarkers (using methods and systems such as Luminex, Nanostring, Olink etc) and/or multiplex PCR
- Experience working with padlock probes and rolling circle amplification
What we offer
- An ambitious, innovative, inclusive and professional environment.
- Being part of building a cross-disciplinary technology at the frontier of its space.
- Nordic level salary with 5 weeks annual paid vacation.
- Stock option program.
We are hiring on a rolling basis. You will be a key part of our scale-up journey and will be joining a high-paced energetic and diverse team.
